Novel innovative catalytic systems such as hydrogen-bond donors and thiourea hybrid catalysts have been developed for the asymmetric synthesis of biologically important pharmaceuticals and natural products. Benzothiadiazines possess a stronger hydrogen-bond donor ability compared to thioureas and exhibit remarkable catalytic performance for the activation of α,β-unsaturated amides. Hybrid thioureas (bearing an arylboronic acid and an ammonium salt) efficiently promote the hetero-Michael addition to α,β-unsaturated carboxylic acids and the O-alkylation of keto enols with 5-chlorofuran-2(5H)-one. These hybrid catalysts enable the first total synthesis of non-racemic avenaol, a noncanonical strigolactone, as well as the asymmetric synthesis of several pharmaceuticals. In addition, this study discovers unique chemical phenomena (i.e., the dual role of benzoic acid as a boron ligand and a proton shuttle, the chirality switch of products by solvent used, and the dynamic kinetic resolution of a racemic electrophile in an S_N2-type reaction).

新的创新催化系统，如氢键供体和硫脲混合催化剂，已被开发用于不对称合成具有重要生物学意义的药物和天然产物。与硫脲相比，苯并噻二嗪具有更强的氢键供体能力，并且对 α,β-不饱和酰胺的活化表现出显着的催化性能。混合硫脲（轴承的芳基硼酸和铵盐）有效地促进杂Michael加成到α，β不饱和羧酸和Ó酮烯醇与5-氯-2-（5-烷基化ħ）-一。这些混合催化剂使非外消旋燕麦醇（一种非经典独脚金内酯）的首次全合成以及多种药物的不对称合成成为可能。此外，这项研究发现了独特的化学现象（即，苯甲酸作为硼配体和质子穿梭的双重作用，所用溶剂对产物的手性转换，以及外消旋亲电子试剂在S _N 2 中的动态动力学分辨率型反应）。