Cases reports: Unintended anti-doping rule violation after dorzolamide use several months prior to a doping control,Drug Testing and Analysis

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Cases reports: Unintended anti-doping rule violation after dorzolamide use several months prior to a doping control
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2021-08-30 , DOI: 10.1002/dta.3156
Andrzej Pokrywka ₁ , Monika Skrzypiec-Spring ₂ , Jarosław Krzywański ₃ , Michał Rynkowski ₄ , Martial Saugy ₅ , Raphael Faiss ₅

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The use of specific medicine up to several months before a doping control is not be reported on the doping control form, while the drug could then still be detectable in urine in case of a very slow elimination. It may lead to a positive test result. For example, dorzolamide, a carbonic anhydrase inhibitor for topical ophthalmic application, has a very slow elimination rate via the renal route (half-life > 4 months). This substance can be a source of unintended anti-doping rule violations.

中文翻译：

案例报告：在兴奋剂检查前几个月使用多佐胺后意外违反反兴奋剂规则

在兴奋剂控制表上没有报告在兴奋剂控制前几个月使用特定药物，而在消除非常缓慢的情况下，仍然可以在尿液中检测到药物。它可能导致阳性测试结果。例如，多佐胺，一种用于眼部局部应用的碳酸酐酶抑制剂，通过肾脏途径的消除速度非常慢（半衰期> 4个月）。这种物质可能是意外违反反兴奋剂规则的来源。

更新日期：2021-10-13

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