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IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33
Allergy ( IF 12.6 ) Pub Date : 2021-08-30 , DOI: 10.1111/all.15072 Alexandra Schröder 1, 2 , Lars P Lunding 1, 2 , Ulrich M Zissler 3, 4 , Christina Vock 2, 5 , Sina Webering 1, 2 , Johanna C Ehlers 2, 5 , Zane Orinska 2, 5 , Adam Chaker 3, 6 , Carsten B Schmidt-Weber 3, 4 , Niklas J Lang 4, 7 , Herbert B Schiller 4, 7 , Marcus A Mall 8, 9, 10 , Heinz Fehrenbach 2, 5 , Charles A Dinarello 11, 12 , Michael Wegmann 1, 2
Allergy ( IF 12.6 ) Pub Date : 2021-08-30 , DOI: 10.1111/all.15072 Alexandra Schröder 1, 2 , Lars P Lunding 1, 2 , Ulrich M Zissler 3, 4 , Christina Vock 2, 5 , Sina Webering 1, 2 , Johanna C Ehlers 2, 5 , Zane Orinska 2, 5 , Adam Chaker 3, 6 , Carsten B Schmidt-Weber 3, 4 , Niklas J Lang 4, 7 , Herbert B Schiller 4, 7 , Marcus A Mall 8, 9, 10 , Heinz Fehrenbach 2, 5 , Charles A Dinarello 11, 12 , Michael Wegmann 1, 2
Affiliation
Children with asthma have impaired production of interleukin (IL) 37; in mice, IL-37 reduces hallmarks of experimental allergic asthma (EAA). However, it remains unclear how IL-37 exerts its inhibitory properties in asthma. This study aimed to identify the mechanism(s) by which IL-37 controls allergic inflammation.
中文翻译:
IL-37 通过平衡促炎性 IL-1 和 IL-33 来调节过敏性炎症
哮喘患儿的白细胞介素 (IL) 生成受损 37;在小鼠中,IL-37 降低了实验性过敏性哮喘 (EAA) 的标志。然而,目前尚不清楚 IL-37 如何在哮喘中发挥其抑制作用。本研究旨在确定 IL-37 控制过敏性炎症的机制。
更新日期:2021-08-30
中文翻译:
IL-37 通过平衡促炎性 IL-1 和 IL-33 来调节过敏性炎症
哮喘患儿的白细胞介素 (IL) 生成受损 37;在小鼠中,IL-37 降低了实验性过敏性哮喘 (EAA) 的标志。然而,目前尚不清楚 IL-37 如何在哮喘中发挥其抑制作用。本研究旨在确定 IL-37 控制过敏性炎症的机制。