IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33,Allergy

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IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33
Allergy ( IF 12.4 ) Pub Date : 2021-08-30 , DOI: 10.1111/all.15072
Alexandra Schröder _{1,

2} , Lars P Lunding _{1,

2} , Ulrich M Zissler _{3,

4} , Christina Vock _{2,

5} , Sina Webering _{1,

2} , Johanna C Ehlers _{2,

5} , Zane Orinska _{2,

5} , Adam Chaker _{3,

6} , Carsten B Schmidt-Weber _{3,

4} , Niklas J Lang _{4,

7} , Herbert B Schiller _{4,

7} , Marcus A Mall _{8,

9,

10} , Heinz Fehrenbach _{2,

5} , Charles A Dinarello _{11,

12} , Michael Wegmann _{1,

2}

Affiliation

Division of Asthma Exacerbation &-Regulation, Priority Area Asthma & Allergy, Research Center Borstel-Leibniz Lung Center, Borstel, Germany.
Airway Research Center North, Member of the German Center for Lung Research (DZL), Munich, Germany.
Center of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.
Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.
Division of Experimental Pneumology, Priority Area Asthma & Allergy, Research Center Borstel- Leibniz Lung Center, Borstel, Germany.
Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical, University of Munich, Munich, Germany.
Institute of Lung Biology and Disease, Helmholtz Zentrum München, Munich, Germany.
Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.
German Center for Lung Research (DZL), associated partner site, Berlin, Germany.
Department of Medicine, University of Colorado Denver, Denver, CO, USA.
Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Children with asthma have impaired production of interleukin (IL) 37; in mice, IL-37 reduces hallmarks of experimental allergic asthma (EAA). However, it remains unclear how IL-37 exerts its inhibitory properties in asthma. This study aimed to identify the mechanism(s) by which IL-37 controls allergic inflammation.

中文翻译：

IL-37 通过平衡促炎性 IL-1 和 IL-33 来调节过敏性炎症

哮喘患儿的白细胞介素 (IL) 生成受损 37；在小鼠中，IL-37 降低了实验性过敏性哮喘 (EAA) 的标志。然而，目前尚不清楚 IL-37 如何在哮喘中发挥其抑制作用。本研究旨在确定 IL-37 控制过敏性炎症的机制。

更新日期：2021-08-30

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