当前位置: X-MOL 学术Resp. Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Oxyhemoglobin concentrations do not support hemoglobinopathy in COVID-19
Respiratory Medicine ( IF 3.5 ) Pub Date : 2021-08-30 , DOI: 10.1016/j.rmed.2021.106597
Patrick Maher 1 , Hamna Zafar 2 , Kusum Mathews 2
Affiliation  

Based on computerized modeling studies, it has been postulated that the severe hypoxemia in COVID-19 may result from impaired oxygen carrying capacity on hemoglobin. Standard pulse oximetry may not detect hypoxemia resulting from hemoglobinopathy, therefore hemoglobin co-oximetry is needed to evaluate this divergence. In a clinical data analysis of a multicenter cohort of hospitalized patients with COVID-19, we found a minimal effect, less than 1%, on the correlation between oxyhemoglobin concentration and predicted oxygen saturation in the presence of COVID-19 infection. This effect is unlikely to explain the clinically significant hypoxia in COVID-19 patients.



中文翻译:

氧合血红蛋白浓度不支持 COVID-19 中的血红蛋白病

根据计算机建模研究,假设 COVID-19 中的严重低氧血症可能是由于血红蛋白的携氧能力受损所致。标准脉搏血氧仪可能无法检测到血红蛋白病引起的低氧血症,因此需要血红蛋白共血氧仪来评估这种差异。在对 COVID-19 住院患者的多中心队列进行的临床数据分析中,我们发现在存在 COVID-19 感染的情况下,氧合血红蛋白浓度与预测氧饱和度之间的相关性影响很小,不到 1%。这种效应不太可能解释 COVID-19 患者临床上显着的缺氧。

更新日期:2021-09-01
down
wechat
bug