The development of T follicular helper cells (Tfh) is a multifactorial process that occurs in multiple stages. After their activation the Tfh cells interact with the B cells to complete their differentiation. During this process, the Tfh cells begin to express canonical molecules such as the transcription factor B-cell lymphoma 6 protein, the CXC chemokine receptors type 5, and the inducible T-cell costimulator, as well as secreting other molecules such as IL-21. This whole process is regulated positively and negatively by several factors so that the best response is offered in the face of diseases of various origins, among them helminthiasis. In this context, the role of circulating Tfh, IL-4 and IgG subtypes is essential for an effective response against these pathogens. In this review, the migration process and the differentiation of Tfh, the regulation, their cell subtypes and the role of Tfh in the context of helminth infections will be addressed.

T 滤泡辅助细胞 (Tfh) 的发育是一个多因素过程，发生在多个阶段。激活后，Tfh 细胞与 B 细胞相互作用以完成分化。在此过程中，Tfh 细胞开始表达经典分子，如转录因子 B 细胞淋巴瘤 6 蛋白、CXC 趋化因子受体 5 和诱导型 T 细胞共刺激物，以及分泌其他分子，如 IL-21 . 整个过程受多种因素的正向和负向调节，以便在面对各种来源的疾病（其中包括蠕虫病）时提供最佳反应。在这种情况下，循环 Tfh、IL-4 和 IgG 亚型的作用对于有效应对这些病原体至关重要。在这篇综述中，迁移过程和 Tfh 的分化，