FEOBV-PET to quantify cortical cholinergic denervation in AD: Relationship to basal forebrain volumetry,Journal of Neuroimaging

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FEOBV-PET to quantify cortical cholinergic denervation in AD: Relationship to basal forebrain volumetry
Journal of Neuroimaging ( IF 2.4 ) Pub Date : 2021-08-31 , DOI: 10.1111/jon.12921
Meghmik Aghourian _{1,

2} , Étienne Aumont _{1,

2} , Michel J Grothe _{3,

4} , Jean-Paul Soucy ₂ , Pedro Rosa-Neto _{2,

5} , Marc-André Bedard _{1,

2}

Affiliation

Fluorine-18-fluoroethoxybenzovesamicol([¹⁸F]-FEOBV) is a PET radiotracer previously used in neurodegenerative diseases to quantify brain cholinergic denervation. The current exploratory study aimed at verifying the reliability of such an approach in Alzheimer's disease (AD) by demonstrating its concordance with MRI volumetry of the cholinergic basal forebrain (ChBF).

中文翻译：

FEOBV-PET 量化 AD 中皮质胆碱能去神经支配：与基底前脑容量的关系

Fluorine-18-fluoroethoxybenzovesamicol([ ¹⁸ F]-FEOBV) 是一种 PET 放射性示踪剂，以前用于神经退行性疾病，以量化脑胆碱能去神经支配。目前的探索性研究旨在通过证明其与胆碱能基底前脑 (ChBF) 的 MRI 体积测量的一致性来验证这种方法在阿尔茨海默病 (AD) 中的可靠性。

更新日期：2021-08-31

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