Objective. Neural cell adhesion molecule (NCAM), a glycoprotein widely distributed in the brain, has recently been shown to regulate neuroplasticity. However, the role of NCAM in vascular dementia (VaD) is still unclear. The purpose of this study is to determine whether NCAM is involved in the course of VaD. Methods. Continuous recruitment of VaD patients and control population to join this study. Doctors or nurses are responsible for collecting their clinical characteristics including age, gender, formal education, heart rate, supine systolic blood pressure, supine diastolic blood pressure, fasting glucose, high-density lipoprotein, and low-density lipoprotein. Each participant received the Montreal Cognitive Assessment (MoCA) scale after being enrolled in the group. At the same time, their peripheral blood was collected, and their serum NCAM levels were measured by enzyme-linked immunosorbent assay (ELISA). Results. 98 VaD patients and 83 age- and sex-matched controls were enrolled. There was no significant statistical difference between the VaD group and the control group in terms of the comparison of clinical characteristics (). The MoCA score of VaD patients was significantly lower than that of the controls ( vs. points, ). In addition, the circulating NCAM level of VaD patients was also significantly lower than that of controls ( vs.  ng/mL, ). The circulating NCAM level of VaD patients was significantly positively correlated with MoCA score (, ). After adjusting for clinical characteristics, circulating NCAM levels are still an independent pathogenic factor of VaD (regression , ). Conclusions. VaD patients have low circulating NCAM levels, which can be used as a potential predictor of VaD.

中文翻译：

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与血管性痴呆认知障碍相关的血清 NCAM 水平降低

客观。神经细胞粘附分子 (NCAM) 是一种广泛分布在大脑中的糖蛋白，最近已被证明可调节神经可塑性。然而，NCAM 在血管性痴呆 (VaD) 中的作用仍不清楚。本研究的目的是确定 NCAM 是否参与 VaD 的过程。方法. 持续招募 VaD 患者和对照人群加入本研究。医生或护士负责收集他们的临床特征，包括年龄、性别、受教育程度、心率、仰卧位收缩压、仰卧位舒张压、空腹血糖、高密度脂蛋白和低密度脂蛋白。每位参与者在入组后都接受了蒙特利尔认知评估 (MoCA) 量表。同时采集外周血，采用酶联免疫吸附试验（ELISA）测定血清NCAM水平。结果. 招募了 98 名 VaD 患者和 83 名年龄和性别匹配的对照。VaD组与对照组临床特征比较差异无统计学意义（）。VaD 患者的 MoCA 评分显着低于对照组（ 对比 点， ）。此外，VaD 患者的循环 NCAM 水平也显着低于对照组（ 对比  纳克/毫升， ）。VaD患者的循环NCAM水平与MoCA评分呈显着正相关（, ）。调整临床特征后，循环 NCAM 水平仍然是 VaD 的独立致病因素（回归, ）。 结论。VaD 患者的循环 NCAM 水平较低，可用作 VaD 的潜在预测因子。