The scientific evidence indicates that calorie restriction and intermittent fasting are among the appropriate strategies targeting factual causative factors of various inflammatory and lifestyle-related disorders. Periodontitis is a common oral inflammatory disease leading to bone loss that is associated with various systemic problems. Previous studies suggest that calorie restriction may dampen inflammation and concomitant tissue damage under inflammatory conditions, such as periodontal diseases in nonhuman primates. However, insufficient research has been carried out to assess the effects of a calorie-restricted diet on the initiation and progression of periodontal disease in humans. This review of the literature aims to describe the general concepts of calorie restriction, its clinical implications, and related therapeutic potential in controlling periodontal inflammation. The review shows that fasting regimen groups have shown lesser bone loss because of an increase in osteoprogenitor cells than non-fasting groups. Calorie restriction dampens the inflammatory response and reduces circulating inflammatory mediators like tumor necrosis factor-alpha, interleukin-6, matrix metalloproteinase-8, matrix metalloproteinase-9, and interleukin-1-beta in gingival crevicular fluid. However, the incorporation of this form of dietary intervention continues to be challenging in our current society, in which obesity is a major public concern. Calorie restriction and intermittent fasting can play a key role in the cost-effective resolution of periodontal inflammation as a primary prevention strategy for the management of chronic inflammatory diseases, including periodontal diseases.

中文翻译：

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热量限制和间歇性禁食对牙周健康的影响

科学证据表明，热量限制和间歇性禁食是针对各种炎症和生活方式相关疾病的实际致病因素的适当策略。牙周炎是一种常见的口腔炎性疾病，会导致与各种全身问题相关的骨质流失。先前的研究表明，在非人类灵长类动物的牙周病等炎症条件下，热量限制可能会抑制炎症和伴随的组织损伤。然而，尚未进行足够的研究来评估热量限制饮食对人类牙周病的发生和发展的影响。这篇文献综述旨在描述热量限制的一般概念、其临床意义、以及控制牙周炎症的相关治疗潜力。该评论表明，由于骨祖细胞的增加，禁食方案组比非禁食组显示出较少的骨质流失。热量限制抑制炎症反应并减少循环炎症介质，如牙龈沟液中的肿瘤坏死因子-α、白细胞介素-6、基质金属蛋白酶-8、基质金属蛋白酶-9 和白细胞介素-1-β。然而，在我们当前的社会中，这种饮食干预形式的结合仍然具有挑战性，其中肥胖是一个主要的公众关注点。热量限制和间歇性禁食可以在牙周炎症的经济有效解决中发挥关键作用，作为慢性炎症疾病管理的一级预防策略，