Genomics research has improved our understanding of the genetic basis for human traits and diseases. This progress is now being translated into clinical care as we move toward a future of precision medicine. Many hope that expanded use of genomic testing will improve disease screening, diagnosis, risk stratification, and treatment. In many respects, cardiovascular medicine is leading this charge. However, most cardiovascular genomics research has been conducted in populations of primarily European ancestry. This bias has critical downstream effects. Here, we review the current disparities in cardiovascular genomics research, and we outline how these disparities propagate forward through all phases of the translational pipeline. If not adequately addressed, biases in genomics research will further compound the existing health disparities that face underrepresented and marginalized populations.

中文翻译：

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心血管基因组学研究中种族差异的传播


基因组学研究提高了我们对人类特征和疾病遗传基础的理解。随着我们迈向精准医疗的未来，这一进步现已转化为临床护理。许多人希望扩大基因组检测的使用将改善疾病筛查、诊断、风险分层和治疗。在许多方面，心血管医学都处于领先地位。然而，大多数心血管基因组学研究都是在主要是欧洲血统的人群中进行的。这种偏差具有严重的下游影响。在这里，我们回顾了当前心血管基因组学研究中的差异，并概述了这些差异如何在转化管道的所有阶段中传播。如果没有得到充分解决，基因组学研究中的偏见将进一步加剧代表性不足和边缘化人群面临的现有健康差距。