Electrochemical Heteroatom-Heteroatom Bond Construction,The Chemical Record

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Electrochemical Heteroatom-Heteroatom Bond Construction
The Chemical Record ( IF 7.0 ) Pub Date : 2021-08-31 , DOI: 10.1002/tcr.202100178
Zhiying Du ₁ , Qiqi Qi ₁ , Wei Gao _{1,

2} , Li Ma ₁ , Zhenxian Liu ₃ , Ruiming Wang ₄ , Jianbin Chen _{1,

3}

Affiliation

Heteroatom-heteroatom linkage, with S−S bond as a presentative motif, served a crucial role in biochemicals, pharmaceuticals, pesticides, and material sciences. Thus, preparation of the privileged scaffold has always been attracting tremendous attention from the synthetic community. However, classic protocols suffered from several drawbacks, such as toxic and unstable agents, poor functional group tolerance, multiple steps, and explosive oxidizing regents as well as the transitional metal catalysts. Electrochemical organic synthesis exhibited a promising alternative to the traditional chemical reaction due to the sustainable electricity can be employed as the traceless redox agents. Hence, toxic and explosive oxidants and/or transitional metals could be discarded under mild reaction with high efficiency. In this context, a series of electrochemical approaches for the construction of heteroatom-heteroatom bond were reviewed. Notably, most of the cases illustrated the dehydrogenative feature with the clean energy molecules hydrogen as the sole by-product.

中文翻译：

电化学杂原子-杂原子键构建

杂原子-杂原子键，以 S-S 键为代表基序，在生化、药物、农药和材料科学中发挥着至关重要的作用。因此，特权支架的制备一直受到合成界的极大关注。然而，经典方案存在一些缺点，例如有毒和不稳定的试剂、官能团耐受性差、步骤多、易爆氧化剂以及过渡金属催化剂。由于可持续的电力可用作无痕氧化还原剂，电化学有机合成展示了传统化学反应的有希望的替代方案。因此，有毒和易爆的氧化剂和/或过渡金属可以在温和的反应下高效地丢弃。在这种情况下，综述了一系列构建杂原子-杂原子键的电化学方法。值得注意的是，大多数案例说明了以清洁能源分子氢作为唯一副产物的脱氢特征。

更新日期：2021-08-31

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