Purpose

This study aimed to investigate differences in static and dynamic functional network connectivity (FNC) and explore their association with neurocognitive performance in acute mild traumatic brain injury (mTBI).

Methods

A total of 76 patients with acute mTBI and 70 age-matched and sex-matched healthy controls were enrolled (age 43.79 ± 10.22 years vs. 45.63 ± 9.49 years; male/female: 34/42 vs. 38/32; all p > 0.05) and underwent resting-state functional magnetic resonance imaging (fMRI) scan (repetition time/echo time = 2000/30 ms, 230 volumes). Independent component analysis was conducted to evaluate static and dynamic FNC patterns on the basis of nine resting-state networks, namely, auditory network (AUDN), dorsal attention network (dAN), ventral attention network (vAN), default mode network (DMN), left frontoparietal network (LFPN), right frontoparietal network (RFPN), somatomotor network (SMN), visual network (VN), and salience network (SN). Spearman’s correlation among aberrances in FNC values, and Montreal cognitive assessment (MoCA) scores was further measured in mTBI.

Results

Compared with controls, patients with mTBI showed wide aberrances of static FNC, such as reduced FNC in DMN–vAN and VN–vAN pairs. The mTBI patients exhibited aberrant dynamic FNC in state 2, involving reduced FNC aberrance in the vAN with AUDN, VN with DMN and dAN, and SN with SMN and vAN. Reduced dFNC in the SN–vAN pair was negatively correlated with the MoCA score.

Conclusion

Our findings suggest that aberrant static and dynamic FNC at the acute stage may contribute to cognitive symptoms, which not only may expand knowledge regarding FNC cognition relations from the static perspective but also from the dynamic perspective.

中文翻译：

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急性轻度创伤性脑损伤伴认知障碍的异常静态和动态功能网络连接

目的

本研究旨在调查静态和动态功能网络连接 (FNC) 的差异，并探讨它们与急性轻度创伤性脑损伤 (mTBI) 中神经认知表现的关系。

方法

共招募了 76 名急性 mTBI 患者和 70 名年龄匹配和性别匹配的健康对照（年龄 43.79 ± 10.22 岁 vs. 45.63 ± 9.49 岁；男性/女性：34/42 vs. 38/32；所有p > 0.05）并接受静息状态功能磁共振成像（fMRI）扫描（重复时间/回波时间 = 2000/30 ms，230 卷）。基于九个静息状态网络，即听觉网络（AUDN）、背侧注意力网络（dAN）、腹侧注意力网络（vAN）、默认模式网络（DMN），进行独立成分分析以评估静态和动态FNC模式、左额顶网络（LFPN）、右额顶网络（RFPN）、躯体运动网络（SMN）、视觉网络（VN）和显着网络（SN）。在 mTBI 中进一步测量了 FNC 值异常与蒙特利尔认知评估 (MoCA) 分数之间的 Spearman 相关性。

结果

与对照组相比，mTBI 患者表现出广泛的静态 FNC 异常，例如 DMN-vAN 和 VN-vAN 对中的 FNC 减少。mTBI 患者在状态 2 中表现出异常的动态 FNC，包括具有 AUDN 的 vAN、具有 DMN 和 dAN 的 VN 以及具有 SMN 和 vAN 的 SN 中的 FNC 异常减少。SN-vAN 对中降低的 dFNC 与 MoCA 评分呈负相关。

结论

我们的研究结果表明，急性期异常的静态和动态 FNC 可能会导致认知症状，这不仅可以从静态角度扩展关于 FNC 认知关系的知识，还可以从动态角度扩展知识。