Atmosphere-Controlled Palladium-Catalyzed Divergent Decarboxylative Cyclization of 2-Iodobiphenyls and α-Oxocarboxylic Acids,Organic Letters

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Atmosphere-Controlled Palladium-Catalyzed Divergent Decarboxylative Cyclization of 2-Iodobiphenyls and α-Oxocarboxylic Acids
Organic Letters ( IF 4.9 ) Pub Date : 2021-08-31 , DOI: 10.1021/acs.orglett.1c02559
Liwei Zhou ₁ , Mingjie Sun ₁ , Fengru Zhou ₁ , Guobo Deng ₁ , Yuan Yang ₁ , Yun Liang ₁

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A novel palladium-catalyzed divergent decarboxylative cyclization of 2-iodobiphenyls and α-oxocarboxylic acids utilizing the atmosphere as a controlled switch is reported. Under the protection of a nitrogen atmosphere, tribenzotropones are synthesized by a [4 + 3] decarboxylative cyclization. Employing a palladium/O₂ system enables a [4 + 2] decarboxylative cyclization to assemble triphenylenes. Notably, preliminary mechanistic studies indicate that the formation of triphenylenes involves a double decarboxylation.

中文翻译：

气氛控制的钯催化 2-碘联苯和 α-氧代羧酸的发散脱羧环化

报道了一种利用大气作为受控开关的新型钯催化的 2-碘联苯和 α-氧代羧酸的发散脱羧环化反应。在氮气氛的保护下，三苯甲酮通过 [4 + 3] 脱羧环化反应合成。采用钯/O ₂系统能够进行[4 + 2]脱羧环化以组装苯并苯。值得注意的是，初步的机理研究表明，苯并苯的形成涉及双脱羧。

更新日期：2021-09-17

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