Long-term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence,European Journal of Neuroscience

当前位置： X-MOL 学术 › Eur. J. Neurosci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Long-term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-08-30 , DOI: 10.1111/ejn.15435
João Ricardo Sato _{1,

2,

3} , Claudinei Eduardo Biazoli _{1,

4} , André Zugman _{2,

3} , Pedro Mario Pan _{2,

3} , Ana Paula Arantes Bueno ₁ , Luciana Monteiro Moura _{1,

2,

3} , Ary Gadelha _{2,

3} , Felipe Almeida Picon _{3,

5} , Edson Amaro _{3,

6} , Giovanni Abrahão Salum _{3,

5} , Euripedes Constantino Miguel _{3,

7} , Luis Augusto Rohde _{3,

5} , Rodrigo Affonseca Bressan _{2,

3} , Andrea Parolin Jackowski _{2,

3}

Affiliation

There is compelling evidence showing that between-subject variability in several functional and structural brain features is sufficient for unique identification in adults. However, individuation of brain functional connectomes depends on the stabilization of neurodevelopmental processes during childhood and adolescence. Here, we aimed to (1) evaluate the intra-subject functional connectome stability over time for the whole brain and for large scale functional networks and (2) determine the long-term identification accuracy or ‘fingerprinting’ for the cortical volumetric profile and the functional connectome. For these purposes, we analysed a longitudinal cohort of 239 children and adolescents scanned in two sessions with an interval of approximately 3 years (age range 6–15 years at baseline and 9–18 years at follow-up). Corroborating previous results using short between-scan intervals in children and adolescents, we observed a moderate identification accuracy (38%) for the whole functional profile. In contrast, identification accuracy using cortical volumetric profile was 95%. Among the large-scale networks, the default-mode (26.8%), the frontoparietal (23.4%) and the dorsal-attention (27.6%) networks were the most discriminative. Our results provide further evidence for a protracted development of specific individual structural and functional connectivity profiles.

中文翻译：

整个儿童期和青春期皮质体积分布和功能性人类连接组的长期稳定性

有令人信服的证据表明，几个功能和结构大脑特征的受试者之间的变异性足以在成人中进行独特的识别。然而，大脑功能连接组的个体化取决于儿童期和青春期神经发育过程的稳定性。在这里，我们的目的是 (1) 评估整个大脑和大规模功能网络随时间推移的受试者内功能连接组稳定性，以及 (2) 确定皮层体积剖面和大脑的长期识别准确性或“指纹”。功能性连接体。出于这些目的，我们分析了一个由 239 名儿童和青少年组成的纵向队列，他们分两次扫描，间隔大约 3 年（基线年龄范围为 6-15 岁，随访年龄范围为 9-18 岁）。使用儿童和青少年的短扫描间隔证实了先前的结果，我们观察到整个功能配置文件的识别准确度为中等 (38%)。相比之下，使用皮质体积剖面的识别准确率为 95%。在大型网络中，默认模式 (26.8%)、额顶 (23.4%) 和背侧注意力 (27.6%) 网络最具辨别力。我们的结果为特定个体结构和功能连通性的长期发展提供了进一步的证据。额顶 (23.4%) 和背侧注意 (27.6%) 网络是最具辨别力的。我们的结果为特定个体结构和功能连通性的长期发展提供了进一步的证据。额顶 (23.4%) 和背侧注意 (27.6%) 网络是最具辨别力的。我们的结果为特定个体结构和功能连通性的长期发展提供了进一步的证据。

更新日期：2021-09-21

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11