Microorganism identification is critical for the early diagnosis and management of infectious endophthalmitis, but traditional culture can yield false-negative results. Nanopore targeted sequencing (NTS) is a third-generation sequencing technique with multiple advantages. This study aimed to test aqueous humour or vitreous fluid samples from presumed cases of infectious endophthalmitis using NTS to evaluate the feasibility of NTS in diagnosing endophthalmitis, especially for culture-negative cases.

中文翻译：

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使用纳米孔靶向测序的眼内炎微生物学诊断

微生物鉴定对于传染性眼内炎的早期诊断和管理至关重要，但传统培养可能会产生假阴性结果。纳米孔靶向测序（NTS）是一种具有多重优势的第三代测序技术。本研究旨在使用 NTS 检测疑似感染性眼内炎病例的房水或玻璃体液样本，以评估 NTS 在诊断眼内炎方面的可行性，特别是对于培养阴性病例。