Background:Acute rheumatic fever in childhood continues to cause serious morbidity despite all developments. The objective of this study was to evaluate the clinical and laboratory characteristics of patients with acute rheumatic fever and to determine the frequency of subclinical carditis and the side effects of the drugs used in the treatment.Methods:The data of patients hospitalised between 2008 and 2018 with the diagnosis of acute rheumatic fever were included in the study. The relationship of gender and age with the frequency of major symptoms and the distribution of the drugs used in the treatment and their side effects were evaluated.Results:Medical records of 102 patients with complete data were reviewed. 56.9% of the patients were male and the mean age was 10.7 ± 1.9 years. The most common distribution of complaints found were arthritis (51%), arthralgia (25.5%) and fever (16.7%). 10.8% of all patients (n = 11) were diagnosed subclinical carditis via echocardiographic evaluation. The frequency of carditis was higher in female patients with a borderline statistical significance (p = 0.05). However, there was no statistically significant difference between gender and arthritis (p = 0.22) and carditis (p > 0.05). Anti-congestive therapy was required in 22% and inotropic treatment was needed in 6.1% cases. Toxic hepatitis developed in four cases during the acetylsalicylic acid treatment.Conclusions:In a 10-year period, detection of subclinical carditis in 10.8% cases supported that echocardiography should be performed as a standard method for the diagnosis of acute rheumatic fever. Patients should be followed closely in terms of hepatic toxicity due to acetylsalicylic acid used in the treatment.

中文翻译：

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急性风湿热：10 年单中心经验：临床和实验室检查结果，亚临床心脏炎和治疗并发症

背景：尽管有各种发展，儿童时期的急性风湿热仍会导致严重的发病率。本研究的目的是评估急性风湿热患者的临床和实验室特征，并确定亚临床心脏炎的发生频率和治疗中使用的药物的副作用。方法：2008 年至 2018 年住院患者的数据诊断为急性风湿热者被纳入研究。评价性别、年龄与主要症状发生频率、治疗用药分布及副作用的关系。结果：查阅资料完整的102例患者的病历。56.9% 的患者为男性，平均年龄为 10.7 ± 1.9 岁。最常见的投诉分布是关节炎（51%）、关节痛（25.5%）和发烧（16.7%）。10.8% 的患者（n = 11）通过超声心动图评估被诊断为亚临床心脏炎。女性患者的心脏炎发生率较高，具有临界统计学意义（p = 0.05）。然而，性别和关节炎（p = 0.22）和心脏炎（p > 0.05）之间没有统计学上的显着差异。22% 需要抗充血治疗，6.1% 需要正性肌力治疗。4例在乙酰水杨酸治疗期间发生中毒性肝炎。结论：10年期间，10.8%的病例检出亚临床心脏炎支持超声心动图作为诊断急性风湿热的标准方法。