Cardiology in the Young ( IF 0.9 ) Pub Date : 2021-08-31 , DOI: 10.1017/s1047951121003504 Yao Wu 1 , Nickie Andescavage 2 , Catherine Lopez 1 , Jessica Lynn Quistorff 1 , Mary T Donofrio 3 , Adré J du Plessis 4 , Catherine Limperopoulos 1, 2, 4, 5
Prenatal maternal stress is associated with adverse offspring outcomes, which may be mediated by maternal stress hormones. However, evidence supporting the association between maternal stress and cortisol levels in high-risk pregnancies is limited. This study aims to determine the relationship between self-reported maternal mental distress and maternal salivary cortisol levels in pregnancies complicated by foetal CHD compared with healthy pregnancies.
Methods:We recruited women with pregnancies complicated by foetal CHD and healthy pregnancies. Maternal saliva was collected between 22 and 40 gestational weeks. Standardized questionnaires measuring stress, depression, and anxiety were completed by patients. Generalized estimating equation was used to evaluate associations between maternal mental distress scales and cortisol levels.
Results:We studied 165 women (55 CHD, 110 controls) and collected 504 cortisol samples (160 CHD, 344 controls). Women carrying CHD foetuses had higher stress, anxiety, and depression scores compared to women carrying healthy foetuses. However, maternal cortisol levels did not significantly differ in CHD and controls. Cortisol levels were higher in women carrying foetuses with functionally single-ventricle versus two-ventricle CHD. In both CHD and controls, there was no significant association between maternal stress, depression or anxiety scores and cortisol levels.
Conclusion:Our data suggest that self-reported maternal stress, anxiety, and depression are not associated with maternal salivary cortisol levels in CHD and healthy pregnancies. The impact of maternal mental distress on foetal health may be through other mediating pathways other than maternal cortisol concentrations.
中文翻译：
先天性心脏病孕妇的母亲精神压力和皮质醇水平
目标：
产前母体压力与不利的后代结局相关，这可能是由母体压力激素介导的。然而，支持高危妊娠中母亲压力与皮质醇水平之间关联的证据有限。本研究旨在确定与健康妊娠相比，妊娠合并胎儿先心病患者自我报告的母亲精神压力与母亲唾液皮质醇水平之间的关系。
方法：我们招募了妊娠合并胎儿冠心病和健康妊娠的女性。在妊娠 22 至 40 周之间收集母体唾液。测量压力、抑郁和焦虑的标准化问卷由患者完成。广义估计方程用于评估母亲精神困扰量表与皮质醇水平之间的关联。
结果：我们研究了 165 名女性（55 名 CHD，110 名对照）并收集了 504 个皮质醇样本（160 名 CHD，344 名对照）。与怀有健康胎儿的女性相比，怀有 CHD 胎儿的女性的压力、焦虑和抑郁评分更高。然而，母体皮质醇水平在冠心病和对照组中没有显着差异。与双心室冠心病相比，怀有功能性单心室胎儿的女性皮质醇水平更高。在冠心病和对照组中，母亲压力、抑郁或焦虑评分与皮质醇水平之间没有显着关联。
结论：我们的数据表明，自我报告的产妇压力、焦虑和抑郁与冠心病和健康妊娠中产妇唾液皮质醇水平无关。母亲精神压力对胎儿健康的影响可能是通过母亲皮质醇浓度以外的其他中介途径。
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