Closure of a patent foramen ovale (PFO) in patients after cryptogenic/cardioembolic stroke is recommended by current guidelines for patients who are 16–60 years of age with a high-risk PFO (class of recommendation A, level of evidence I). The use of double-disk occlusion devices followed by antiplatelet therapy is recommended. The procedure of interventional PFO closure compared with other interventions in cardiology is rather easy to learn. However, it should be performed carefully to avoid postinterventional complications. The number needed to treat (NNT) to avoid one stroke in 5 years in the RESPECT trial was 42, in the CLOSE trial even lower with 20. In the REDUCE trial, the NNT was 28 at 2 years. This can be reduced by longer follow-up, e.g., at 10 years the NNT is 18. While other conditions such as migraine are currently under investigation with respect to the impact of PFO closure, sufficiently powered trials are lacking so that closure in diseases other than stroke should always be individualized.

对于 16-60 岁高危 PFO 患者，现行指南推荐在隐源性/心源性卒中后关闭卵圆孔未闭（PFO）（推荐级别 A，证据水平 I）。推荐使用双盘封堵器，然后进行抗血小板治疗。与心脏病学中的其他干预措施相比，介入性 PFO 闭合的过程相当容易学习。但是，应谨慎执行以避免介入后并发症。在 RESPECT 试验中，为避免 5 年内发生一次卒中而需要治疗的人数 (NNT) 为 42，在 CLOSE 试验中甚至更低，为 20。在 REDUCE 试验中，NNT 在 2 年时为 28。这可以通过更长时间的随访来减少，例如，在 10 年时 NNT 为 18。