Host under epigenetic control: A novel perspective on the interaction between microorganisms and corals,BioEssays

当前位置： X-MOL 学术 › BioEssays › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Host under epigenetic control: A novel perspective on the interaction between microorganisms and corals
BioEssays ( IF 3.2 ) Pub Date : 2021-08-31 , DOI: 10.1002/bies.202100068
Adam R Barno ₁ , Helena D M Villela ₁ , Manuel Aranda ₁ , Torsten Thomas ₂ , Raquel S Peixoto _{1,

3}

Affiliation

Coral reefs have been challenged by the current rate and severity of environmental change that might outpace their ability to adapt and survive. Current research focuses on understanding how microbial communities and epigenetic changes separately affect phenotypes and gene expression of corals. Here, we provide the hypothesis that coral-associated microorganisms may directly or indirectly affect the coral's phenotypic response through the modulation of its epigenome. Homologs of ankyrin-repeat protein A and internalin B, which indirectly cause histone modifications in humans, as well as Rv1988 histone methyltransferase, and the DNA methyltransferases Rv2966c, Mhy1, Mhy2, and Mhy3 found in coral-associated bacteria indicate that there are potential host epigenome-modifying proteins in the coral microbiome. With the ideas presented here, we suggest that microbiome manipulation may be a means to alter a coral's epigenome, which could aid the current efforts to protect coral reefs. Also see the video abstract here: https://youtu.be/CW9GbChjKM4

中文翻译：

表观遗传控制下的宿主：微生物与珊瑚相互作用的新视角

当前环境变化的速度和严重程度可能超过珊瑚礁的适应和生存能力，这对珊瑚礁造成了挑战。目前的研究重点是了解微生物群落和表观遗传变化如何分别影响珊瑚的表型和基因表达。在这里，我们假设珊瑚相关微生物可能通过调节其表观基因组直接或间接影响珊瑚的表型反应。锚蛋白重复蛋白 A 和内蛋白 B 的同源物（间接导致人类组蛋白修饰），以及 Rv1988 组蛋白甲基转移酶，以及在珊瑚相关细菌中发现的 DNA 甲基转移酶 Rv2966c、Mhy1、Mhy2 和 Mhy3 表明存在潜在宿主珊瑚微生物组中的表观基因组修饰蛋白。有了这里提出的想法，我们认为微生物组操作可能是改变珊瑚表观基因组的一种手段，这可能有助于当前保护珊瑚礁的努力。另请参阅此处的视频摘要：https://youtu.be/CW9GbChjKM4

更新日期：2021-09-27

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11