Background

Time restricted feeding (TRF) involves confining the eating window to a specific number of hours, and fasting for the remaining hours of the day.

Objective

This study examined if changes in body weight and metabolic risk factors during TRF, differ between premenopausal and postmenopausal women.

Methods

This is a secondary analysis of an 8-week TRF study (4–6 h eating window, 18–20 h fasting window daily) conducted in adults with obesity. Male participants were excluded, and female subjects were classified in two groups based on menstrual status: premenopausal (n = 13), or postmenopausal (n = 19). Perimenopausal women were excluded from the original study.

Results

Body weight decreased by week 8 in premenopausal women (−3.3 ± 0.4%) and postmenopausal women (−3.3 ± 0.5%) (main effect of time, P < 0.001), with no difference between groups (no group × time interaction). Adherence was excellent in both groups, with premenopausal women adhering to their prescribed eating window on 6.2 ± 0.1 d/week, and postmenopausal women adhering to their window on 6.2 ± 0.2 d/week. Fat mass, lean mass, fasting insulin, insulin resistance, and 8-isoprostane (marker of oxidative stress) were reduced similarly in both groups (main effect of time, P < 0.05 for all comparisons). Visceral fat mass, relative skeletal muscle index (RSMI), blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, HbA1c, TNF-alpha and IL-6 remained unchanged in both groups by week 8.

Conclusion

These findings suggest that the weight loss and metabolic benefits of TRF do not differ between premenopausal and postmenopausal women with obesity.

中文翻译：

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绝经前与绝经后女性在限时喂养期间体重和代谢风险的变化

背景

限时进食 (TRF) 包括将进食窗口限制在特定的小时数内，并在一天中的剩余时间内禁食。

客观的

这项研究检验了绝经前和绝经后女性在 TRF 期间体重和代谢危险因素的变化是否存在差异。

方法

这是对肥胖成人进行的 8 周 TRF 研究（每天 4-6 小时进食窗口，18-20 小时禁食窗口）的二次分析。男性参与者被排除在外，女性受试者根据月经状况分为两组：绝经前（n  = 13）或绝经后（n  = 19）。围绝经期妇女被排除在最初的研究之外。

结果

绝经前女性 (−3.3 ± 0.4%) 和绝经后女性 (−3.3 ± 0.5%) 体重在第 8 周下降（时间的主效应，P  < 0.001），组间没有差异（没有组 × 时间交互作用）。两组的依从性都非常好，绝经前女性每周坚持 6.2 ± 0.1 天的规定饮食窗口，绝经后女性每周坚持 6.2 ± 0.2 天的规定饮食窗口。两组的脂肪量、去脂体重、空腹胰岛素、胰岛素抵抗和 8-异前列腺素（氧化应激标志物）的降低程度相似（时间的主效应，P 所有比较均 < 0.05）。到第 8 周时，两组的内脏脂肪量、相对骨骼肌指数 (RSMI)、血压、LDL 胆固醇、HDL 胆固醇、甘油三酯、空腹血糖、HbA1c、TNF-α 和 IL-6 均保持不变。

结论

这些发现表明，TRF 的减肥和代谢益处在绝经前和绝经后肥胖女性之间没有差异。