Objective: Investigate the CEUS enhancement patterns of PDAC and analyse correlations between the CEUS enhancement pattern and both the degree of tumour tissue differentiation and overall survival (OS).
Methods: The study included 56 patients with locally advanced PDAC, performed conventional ultrasound and CEUS, and analysed characteristics of the CEUS enhancement patterns. In addition, clinical data, such as serum level of CA19-9, TNM stage were collected, and patients’ survival times were followed up. TICs of dynamic CEUS images were acquired using image processing software to obtain the peak, TP, sharpness, and AUC. Correlations of the CEUS enhancement patterns of PDAC with the degree of differentiation of tumour tissue and OS were quantitatively analysed, as were the correlations of the TIC parameters and CEUS enhancement patterns with OS.
Results: Enhancement in the arterial phase included iso-enhancement (30.3%) and hypo-enhancement (69.6%), and was not significantly correlated with sex, age at disease onset, or lesion size. Also was not significantly correlated with tumour tissue differentiation. Clear survival times were obtained for 50 patients during follow-up, and the median survival time was significantly longer for the patients with iso-enhancement than hypo-enhancement. Among the TIC parameters, peak_tumour, sharpness_tumour, AEsharpness, and REsharpness differed significantly between the group with iso-enhancement and hypo-enhancement (p < 0.05).
Conclusion: The CEUS enhancement patterns of PDAC in the arterial phase include iso-enhancement and hypo-enhancement. Enhancement pattern was not significantly correlated with the degree of differentiation of tumour tissue, but patient survival time differed significantly between the two enhancement patterns, with longer survival for patients with iso-enhancement.

Keywords: contrast-enhanced ultrasound, pancreatic ductal adenocarcinoma, survival time, enhancement pattern, time-intensity curve


中文翻译：

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经腹超声增强模式与胰腺导管腺癌生存率的相关性

目的：研究PDAC的CEUS增强模式，分析CEUS增强模式与肿瘤组织分化程度和总生存期（OS）的相关性。
方法：该研究包括 56 名局部晚期 PDAC 患者，进行了常规超声和 CEUS，并分析了 CEUS 增强模式的特征。此外，收集血清CA19-9水平、TNM分期等临床资料，并随访患者生存时间。使用图像处理软件获取动态 CEUS 图像的 TIC，以获得峰值、TP、锐度和 AUC。定量分析 PDAC 的 CEUS 增强模式与肿瘤组织和 OS 的分化程度的相关性，以及 TIC 参数和 CEUS 增强模式与 OS 的相关性。
结果：动脉期增强包括等增强（30.3%）和低增强（69.6%），与性别、发病年龄或病变大小无显着相关性。与肿瘤组织分化也无显着相关性。50 例患者在随访期间获得了明确的生存时间，等增强患者的中位生存时间明显长于低增强患者。在 TIC 参数中，峰值_肿瘤、锐度_肿瘤、AEsharpness 和 REsharpness 在等增强组和低增强组之间存在显着差异（p < 0.05）。
结论：PDAC在动脉期的CEUS增强模式包括等增强和低增强。增强模式与肿瘤组织的分化程度无显着相关性，但两种增强模式的患者存活时间存在显着差异，等增强的患者存活时间更长。

【关键词】：超声造影 胰腺导管腺癌 生存时间 强化模式 时间-强度曲线