Maslinic acid, a naturally occurring pentacyclic triterpene in more than 30 plants (including olives), reportedly increases human muscle mass and muscle strength; however, the underlying molecular mechanism remains unknown. C57BL/6J mice were fed a standard diet or supplemented with 0.27% maslinic acid for 4 weeks, and their skeletal muscle mass was measured. Mice that consumed maslinic acid displayed significant increases in gastrocnemius and soleus muscle mass. Cultured mouse-C2C12 skeletal muscle cells were treated with mammalian target of rapamycin complex 1 (mTORC1) or protein kinase b (Akt) inhibitor, and protein synthesis was quantified. Maslinic acid accelerated protein synthesis via mTORC1 activation independent of Akt. Furthermore, maslinic acid activated human Takeda G protein-coupled receptor 5 (TGR5) more strongly than mouse TGR5, augmenting the expression of several genes related to muscular hypertrophy. Maslinic acid activated mTORC1 and human TGR5, implying its contribution to human muscular hypertrophy through these effects.

中文翻译：

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山楂酸激活 mTORC1 和人 TGR5 并诱导骨骼肌肥大。


山楂酸是 30 多种植物（包括橄榄）中天然存在的五环三萜，据报道可增加人体肌肉质量和肌肉力量；然而，潜在的分子机制仍然未知。 C57BL/6J小鼠被喂食标准饮食或补充0.27%山楂酸4周，并测量它们的骨骼肌质量。食用山楂酸的小鼠腓肠肌和比目鱼肌质量显着增加。用哺乳动物雷帕霉素靶点复合物 1 (mTORC1) 或蛋白激酶 b (Akt) 抑制剂处理培养的小鼠 C2C12 骨骼肌细胞，并对蛋白质合成进行定量。山楂酸通过独立于 Akt 的 mTORC1 激活加速蛋​​白质合成。此外，山楂酸比小鼠 TGR5 更强烈地激活人武田 G 蛋白偶联受体 5 (TGR5)，从而增强了与肌肉肥大相关的多个基因的表达。山楂酸激活 mTORC1 和人类 TGR5，这意味着它通过这些作用促进人类肌肉肥大。