Pain perception in chronic pancreatitis (CP) is governed by the transmission of nociceptive inputs into the pain processing centers of the brain. These regions of the brain overlap with those that regulate and process emotions and cognition. Disorders in these regions also result in psychiatric conditions such as depression, anxiety, and posttraumatic stress disorder. The present study by Dunbar et al. evaluated 24 single nucleotide polymorphisms associated with anxiety and/or posttraumatic stress disorder and found correlations with constant and severe pain phenotypes in CP patients from a large cross-sectional cohort study. Although causation cannot be proven, the findings suggest that there may be a role for neuromodulator drugs for the treatment of pain in CP based on individual genetic susceptibility.

中文翻译：

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慢性胰腺炎的精神疾病易感性和疼痛：关联还是因果关系？

慢性胰腺炎 (CP) 的疼痛感知受伤害性输入传递到大脑疼痛处理中心的控制。大脑的这些区域与调节和处理情绪和认知的区域重叠。这些区域的疾病还会导致精神疾病，例如抑郁、焦虑和创伤后应激障碍。Dunbar 等人的本研究。评估了与焦虑和/或创伤后应激障碍相关的 24 个单核苷酸多态性，并从一项大型横断面队列研究中发现了与 CP 患者持续和严重疼痛表型的相关性。尽管无法证明因果关系，但研究结果表明，基于个体遗传易感性，神经调节药物可能在治疗 CP 疼痛方面发挥作用。