Sheep-induced pluripotent stem cells (siPSCs) have low reprogramming efficiency, thereby hampering their use in biotechnology and agriculture. Several studies have shown that some microRNAs play an important role in promoting somatic reprogramming in mouse and human. In this study, we investigated the effect of miR-200c-141 on somatic reprogramming in sheep and explored the mechanism of promoting the reprogramming.

中文翻译：

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miR-200c-141 通过靶向 ZEB1 增强绵羊肾细胞重编程为多能细胞。

绵羊诱导的多能干细胞 (siPSC) 的重编程效率低，从而影响了它们在生物技术和农业中的应用。多项研究表明，一些 microRNA 在促进小鼠和人类体细胞重编程方面发挥着重要作用。在这项研究中，我们研究了 miR-200c-141 对绵羊体细胞重编程的影响，并探索了促进重编程的机制。