The Present study deals with synthesis of PVC/ABS/ZnO nanocomposites with Zinc oxide nanoparticles of particle size less than 50 nm by sonication and solution casting techniques. After characterization, such nanocomposite materials were subjected to thermal study, antibiofilm, antibacterial and antioxidant screening. Nanocomposites films showed higher thermal stability than pure polymer matrix loaded with different ZnO-Nps concentration with homogeneous distribution. Antibacterial studies were carried out against selected gram-positive bacteria: Staphylococcus aureus and gram-negative bacteria: Pseudomonas aeruginosa. Selective antibiofilm activity was studied against Staphylococcus aureus and Pseudomonas aeruginosa, which showed a higher to lower activity as a model pathogenic strains (∼93 and ∼89 at 160 µg/ml concentration, respectively), while free radical scavenging capacity was assessed by DPPH, ABTH^·+ and FRAP methods. PVC/ABS/ZnO nanocomposite showed larger zones of inhibition and higher antibiofilm and antioxidant activity than PVC/ABS polymer matrix. PVC/ABS/ZnO nanocomposite showed enhanced thermal stability and biological properties that qualify them for different biomedical and industrial applications.

本研究涉及通过超声处理和溶液浇铸技术合成具有粒径小于 50 nm 的氧化锌纳米颗粒的 PVC/ABS/ZnO 纳米复合材料。表征后，对此类纳米复合材料进行热研究、抗生物膜、抗菌和抗氧化剂筛选。纳米复合材料薄膜表现出比负载不同 ZnO-Nps 浓度且分布均匀的纯聚合物基体更高的热稳定性。对选定的革兰氏阳性菌：金黄色葡萄球菌和革兰氏阴性菌：铜绿假单胞菌进行了抗菌研究。研究了针对金黄色葡萄球菌和铜绿假单胞菌的选择性抗生物膜活性，作为模型致病菌株显示出较高到较低的活性（分别为~93 和~89，浓度为 160 µg/ml），而自由基清除能力则通过 DPPH、ABTH ^·+和 FRAP 方法进行评估。与 PVC/ABS 聚合物基质相比，PVC/ABS/ZnO 纳米复合材料显示出更大的抑制区域和更高的抗生物膜和抗氧化活性。PVC/ABS/ZnO 纳米复合材料显示出增强的热稳定性和生物特性，使其适合不同的生物医学和工业应用。