当前位置: X-MOL 学术Jpn. J. Infect. Dis. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Complete genome sequencing and comparative analysis of Citrobacter koseri CKNJ, a strain isolated from patient with endogenous endophthalmitis
Japanese Journal of Infectious Diseases ( IF 1.3 ) Pub Date : 2021-08-31 , DOI: 10.7883/yoken.jjid.2021.334
Qiaoyan Yue 1, 2 , Qiyue Zhang 2 , Yueqin Wang 2 , Xiaoju He 2 , Kang Ding 3 , Xiaofeng Wang 3 , Haiyan Xi 4 , Lulu Wang 4 , Yanliang Zhang 2 , Chao Wu 1
Affiliation  

Citrobacter koseri is an opportnistic pathogen can cause a variety of diseases. Though the mortality rate of C. koseri infections is high but there is a paucity of clinical information on them. Furthermore, the genomic features of this species are poorly studied. Herein, we presented a patient with endogenous endophthalmitis secondary to septicaemia, and collected a C. koseri isolate, CKNJ, from the blood of the patient. Whole genome sequencing revealed that the CKNJ harbors no plasmid and codes for 67 putative virulence factors. Whole genome SNP-based phylogenetic analysis revealed that strain CKNJ was close to the strains with same isolation sites. Compared to the other sequenced C. koseri chromosomes, CKNJ contains several strain-variable regions, including one prophage and two large genomic islands. The sequencing of the first complete genome of a clinical strain from China should reinforce our understanding of the genomic features and pathogenicity of this invasive infection-causing C. koseri with clinical significance.

更新日期:2021-08-30
down
wechat
bug