Campylobacter jejuni is a major foodborne pathogen causing enteritis in humans and is also known as an antecedent infectious factor for Guillain-Barré syndrome (GBS). The onset of GBS after C. jejuni infection results from molecular mimicry between human neuronal ganglioside and C. jejuni lipooligosaccharide (LOS). C. jejuni HS:19 has been previously reported to be isolated from GBS cases more frequently than other serotypes in Japan. Therefore, in this study, we performed molecular analysis of 88 HS:19 isolates from GBS cases, sporadic diarrheal patients, and poultry meats using multi-locus sequence typing and LOS class analysis. As a result, 87 of the 88 HS:19 isolates were typed as ST22 / CC22 and LOS class A1, while one was typed as ST1947 / CC22 and LOS class A1. Furthermore, the analysis of other 331 isolates from sporadic enteritis cases shows that only 34 (10.3%) were typed as LOS class A, including HS:19 (25 isolates), HS:2 (8 isolates), and HS:4c (1 isolate). In conclusion, C. jejuni HS:19 had high clonality, regardless of its origin, over other capsule types in Japan.

空肠弯曲 杆菌是引起人类肠炎的主要食源性病原体，也被称为格林-巴利综合征 (GBS) 的先行感染因子。C后 GBS 发病。空肠感染是由人类神经元神经节苷脂和C之间的分子模拟引起的。空肠寡糖（LOS）。C. _ 空肠据报道，HS:19 在日本比其他血清型更频繁地从 GBS 病例中分离出来。因此，在本研究中，我们使用多位点序列分型和 LOS 分类分析对来自 GBS 病例、散发性腹泻患者和禽肉的 88 株 HS:19 株进行了分子分析。结果，88 个 HS:19 分离株中有 87 个被分型为 ST22 / CC22 和 LOS A1 类，而一个被分型为 ST1947 / CC22 和 LOS A1 类。此外，对其他 331 株散发性肠炎病例的分析表明，只有 34 株（10.3%）被分类为 LOS A 类，包括 HS：19（25 株）、HS：2（8 株）和 HS：4c（1隔离）。总之，C . jejuni HS:19 与日本的其他胶囊类型相比，无论其来源如何，都具有较高的克隆性。