From August 27 to October 15, 2014, a dengue fever outbreak with 158 autochthonous cases occurred after nearly 70 years of no reports of autochthonous cases in Japan. The most competent mosquito vector for dengue virus (DENV) transmission in Japan is Aedes albopictus. Since A. albopictus is widely distributed throughout Japan, we examined the susceptibility of this species to infection by DENV and the relationship of the endosymbiont Wolbachia (wAlbA and wAlbB) with susceptibility to DENV. The A. albopictus YYG strain, collected from Yoyogi Park in 2014, the epicenter of the dengue fever outbreak, was found to have lower susceptibility to DENV 1 and 3 than that of indigenous Japanese strains A. albopictus EBN 201808 (F1 from the field) and A. albopictus ISG 201603. Further, the A. albopictus EBN 201808 strain showed a same susceptibility to DENV3 as A. albopictus ISG 201603tet strain (Wolbachia-free). Susceptibility to DENV3 was not related to Wolbachia strains wAlbA or wAlbB in the A. albopictus ISG 201603 strain.

2014 年 8 月 27 日至 10 月 15 日，在日本近 70 年无本土病例报告后，发生了登革热疫情，共有 158 例本土病例。在日本传播登革热病毒 (DENV) 最有效的蚊媒是白纹伊蚊。由于A. albopictus在日本广泛分布，我们检查了该物种对 DENV 感染的易感性以及内共生Wolbachia（w AlbA 和w AlbB）与 DENV 易感性的关系。A. albopictusYYG 株于 2014 年从登革热爆发的中心代代木公园采集，被发现对 DENV 1 和 3 的易感性低于日本本土株A. albopictus EBN 201808（来自田间的 F1）和A. albopictus ISG 201603。此外，A. albopictus EBN 201808 菌株对 DENV3 的敏感性与A. albopictus ISG 201603tet 菌株（无沃尔巴克氏体）相同。对 DENV3 的易感性与A. albopictus ISG 201603 菌株中的Wolbachia菌株w AlbA 或w AlbB 无关。