Background

Parkinson’s disease (PD) is the second most common neurodegenerative disease. Evidence has shown that lipocalin-2 (LCN2) is involved in the pathological process of PD. We aimed to explore whether serum levels of LCN2 could be a biomarker of PD.

Methods

We recruited consecutive PD patients and healthy controls (HC) in our hospital from June 2020 to July 2020. Serum LCN2 levels were detected using the LCN2 enzyme-linked immunosorbent assay (ELISA) kit. The motor section of the Unified Parkinson’s Disease Rating Scale (UPDRS III) and the Hoehn and Yahr Staging Scale (H&Y) were assessed on admission to evaluate disease severity in patients with PD. Cognitive status was measured by the Montreal Cognitive Assessment (MoCA).

Results

We finally recruited 75 patients, including 40 PD patients and 35 HC. Serum LCN2 levels were not significantly increased in PD patients compared with HC (4.9 [− 0.7 to 18.6] vs 1.9 [− 1.5 to 16.9] ng/mL, P = 0.33). Besides, there was no significant difference in LCN2 levels between patients at early and advanced stage of PD (P = 0.75), as well as between cognitively impaired PD patients, PD patients with normal cognition, and HC (P = 0.30). Moreover, LCN2 had no correlation with disease duration (r = − 0.1, P = 0.37), UPDRS III score (r = 0.07, P = 0.65), and MoCA score (r = 0.221, P = 0.17).

Conclusions

Overall, our study suggests that serum LCN2 levels may not be a biomarker for PD.

中文翻译：

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帕金森病患者血清脂质运载蛋白 2 水平

背景

帕金森病 (PD) 是第二常见的神经退行性疾病。有证据表明lipocalin-2（LCN2）参与了PD的病理过程。我们旨在探索 LCN2 的血清水平是否可以作为 PD 的生物标志物。

方法

我们从 2020 年 6 月至 2020 年 7 月在我院招募了连续的 PD 患者和健康对照 (HC)。使用 LCN2 酶联免疫吸附试验 (ELISA) 试剂盒检测血清 LCN2 水平。在入院时评估统一帕金森病评定量表 (UPDRS III) 和 Hoehn 和 Yahr 分期量表 (H&Y) 的运动部分，以评估 PD 患者的疾病严重程度。认知状态由蒙特利尔认知评估（MoCA）测量。

结果

我们最终招募了 75 名患者，包括 40 名 PD 患者和 35 名 HC。与 HC 相比，PD 患者的血清 LCN2 水平没有显着增加（4.9 [- 0.7 至 18.6] vs 1.9 [- 1.5 至 16.9] ng/mL，P  = 0.33）。此外，PD早期和晚期患者（P  = 0.75）以及认知障碍PD患者、认知正常PD患者和HC之间（P  = 0.30）LCN2水平无显着差异。此外，LCN2 与病程 ( r  = - 0.1, P  = 0.37)、UPDRS III 评分 ( r  = 0.07, P  = 0.65) 和 MoCA 评分 ( r  = 0.221, P  = 0.17) 没有相关性。

结论

总体而言，我们的研究表明血清 LCN2 水平可能不是 PD 的生物标志物。