Catalyst-Controlled Chemoselective Nitrene Transfers,Helvetica Chimica Acta

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Catalyst-Controlled Chemoselective Nitrene Transfers
Helvetica Chimica Acta ( IF 1.5 ) Pub Date : 2021-08-30 , DOI: 10.1002/hlca.202100140
Hidetoshi Noda ₁ , Xinxin Tang ₁ , Masakatsu Shibasaki ₂

Affiliation

Transition metal catalyzed nitrene transfers provide nitrogen containing compounds through C−H bond insertion, aziridination of olefins, and other types of reactions. Given the importance of these compounds in natural products and pharmaceuticals, tremendous efforts have been devoted to the development of efficient and reliable catalytic methods. In particular, the last decade has seen a remarkable progress in catalyst-controlled chemoselective nitrene transfers, wherein different products can be obtained from a single substrate by the choice of catalyst. This Minireview covers this important and emerging area. We explain the principle of catalyst-controlled synthesis, followed by highlighting literature examples for intra- and intermolecular reactions with an emphasis on the understanding of the nature of reactive intermediates and the strategy needed to realize selectivity. Finally, future directions are discussed based on the literature precedents.

中文翻译：

催化剂控制的化学选择性氮烯转移

过渡金属催化的氮烯转移通过 C-H 键插入、烯烃的氮丙啶化和其他类型的反应提供含氮化合物。鉴于这些化合物在天然产物和药物中的重要性，人们付出了巨大的努力来开发高效可靠的催化方法。特别是，过去十年在催化剂控制的化学选择性氮烯转移方面取得了显着进展，其中通过选择催化剂可以从单一底物获得不同的产物。本小评涵盖了这一重要且新兴的领域。我们解释了催化剂控制合成的原理，然后重点介绍分子内和分子间反应的文献示例，重点是对反应中间体性质的理解以及实现选择性所需的策略。最后，根据文献先例讨论了未来的方向。

更新日期：2021-08-30

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