Scaphoid fractures are difficult to diagnose with current imaging modalities. It is unknown whether the shape of the scaphoid bone, assessed by statistical shape modeling, can be used to differentiate between fractured and non-fractured bones. Therefore, the aim of this study was to investigate whether the presence of a scaphoid fracture is associated with shape modes of a statistical shape model (SSM). Forty-one high-resolution peripheral quantitative computed tomography (HR-pQCT) scans were available from patients with a clinically suspected scaphoid fracture of whom 15 patients had a scaphoid fracture. The scans showed no motion artefacts affecting bone shape. The scaphoid bones were semi-automatically contoured, and the contours were converted to triangular meshes. The meshes were registered, followed by principal component analysis to determine mean shape and shape modes describing shape variance. The first five out of the forty shape modes cumulatively explained 87.8% of the shape variance. Logistic regression analysis was used to study the association between shape modes and fracture presence. The regression models were used to classify the 41 scaphoid bones as fractured or non-fractured using a cut-off value that maximized the sum of sensitivity and specificity. The classification of the models was compared with fracture diagnosis on HR-pQCT. A regression model with four shape modes had an area under the ROC-curve of 72.3% and correctly classified 75.6% of the scaphoid bones (fractured: 60.0%, non-fractured: 84.6%). To conclude, fracture presence in patients with a clinically suspected scaphoid fracture appears to be associated with the shape of the scaphoid bone.

目前的成像方式很难诊断舟状骨骨折。尚不清楚通过统计形状模型评估的舟状骨的形状是否可用于区分骨折和非骨折骨。因此，本研究的目的是调查舟状骨骨折的存在是否与统计形状模型 (SSM) 的形状模式相关。41 次高分辨率外周定量计算机断层扫描 (HR-pQCT) 扫描可从临床疑似舟骨骨折的患者中获得，其中 15 名患者患有舟骨骨折。扫描显示没有影响骨骼形状的运动伪影。舟骨半自动轮廓，轮廓转换为三角形网格。网格被注册，然后进行主成分分析以确定平均形状和描述形状方差的形状模式。四十种形状模式中的前五种累积解释了 87.8% 的形状方差。Logistic 回归分析用于研究形状模式与裂缝存在之间的关联。回归模型用于将 41 块舟状骨分类为骨折或非骨折，使用临界值最大化敏感性和特异性的总和。将模型的分类与 HR-pQCT 上的骨折诊断进行比较。具有四种形状模式的回归模型的 ROC 曲线下面积为 72.3%，正确分类了 75.6% 的舟骨（骨折：60.0%，未骨折：84.6%）。总结一下，