Herein, the Cu₂O yolk-shell nanospheres, nanocubes and microcubes were successfully prepared by a simple seed-medium process. The formation of the Cu₂O yolk-shell nanospheres can be attributed to the self-assembly process caused by the introduction of the seed medium. The formation mechanism of our obtained Cu₂O yolk-shell nanospheres and the dependence of Cu₂O morphology on different surfactants have been studied. The obtained samples were applied in the field of non-enzymatic glucose detection. The electrochemical response characteristics of the modified electrodes toward glucose were investigated by cyclic voltammetry (CV) and chronoamperometry (CA). The electrode modified with C-Cu₂O (obtained by using CTAB as surfactant) shared the highest sensitivity of 3123 μAmM⁻¹ cm^-2, whereas, the electrode modified with S-Cu₂O (obtained by using SDBS as surfactant) exhibited the lowest LOD of 0.87 μM and the widest linear range of 0.05–10.65 mM. All obtained sensors showed fast response to the addition of glucose. The obtained electrodes showed better responses to glucose than other coexisting interferences, indicating that the obtained electrodes had the acceptable selectivity to glucose. In addition, the stability for 5 consecutive weeks had also been studied and exhibited satisfactory results. The obtained electrode was also used to detect the glucose content in real serum. The acceptable selectivity, stability together with the excellent sensing ability in real serum make the obtained electrodes a potential for practical applications.

在此，Cu ₂ O 蛋黄-壳纳米球、纳米立方体和微立方体通过简单的种子-培养基工艺成功制备。Cu ₂ O 蛋黄壳纳米球的形成可归因于引入种子培养基引起的自组装过程。研究了我们获得的 Cu ₂ O 蛋黄-壳纳米球的形成机制以及 Cu ₂ O 形态对不同表面活性剂的依赖性。所得样品应用于非酶法葡萄糖检测领域。通过循环伏安法 (CV) 和计时电流法 (CA) 研究了修饰电极对葡萄糖的电化学响应特性。C-Cu ₂改性电极O（通过使用 CTAB 作为表面活性剂获得）具有 3123 μAmM ^-1 cm ^-2的最高灵敏度，而用 S-Cu ₂修饰的电极O（通过使用 SDBS 作为表面活性剂获得）表现出 0.87 μM 的最低 LOD 和 0.05-10.65 mM 的最宽线性范围。所有获得的传感器都显示出对添加葡萄糖的快速响应。所得电极对葡萄糖的响应优于其他共存干扰物，表明所得电极对葡萄糖具有可接受的选择性。此外，还研究了连续 5 周的稳定性，并显示出令人满意的结果。所得电极还用于检测真实血清中的葡萄糖含量。可接受的选择性、稳定性以及在真实血清中优异的传感能力使所获得的电极具有实际应用的潜力。