Computers & Mathematics with Applications ( IF 2.9 ) Pub Date : 2021-08-30 , DOI: 10.1016/j.camwa.2021.08.007 J.S. Borges 1, 2 , J.A. Ferreira 3 , G. Romanazzi 1 , E. Abreu 1
Drug release from viscoelastic polymeric matrices is a complex phenomenon where the main actors are the fluid, the polymeric structure and the drug. As the fluid enters into the polymer, the polymeric chains relax inducing a resistance to the fluid entrance. In contact with the fluid, a dissolution processes takes place and the dissolved drug diffuses through the medium. Our main goal in this paper is to propose a stable finite difference method that leads to supraconvergent approximations for the fluid, solid and dissolved drug concentrations. The analysis proposed is non-standard in the sense that the error estimates have an important role in the stability analysis.
中文翻译:
从粘弹性聚合物基质中释放药物 - 一种稳定且超收敛的 FDM
从粘弹性聚合物基质中释放药物是一种复杂的现象,其中主要因素是流体、聚合物结构和药物。当流体进入聚合物时,聚合物链松弛,从而对流体入口产生阻力。与流体接触时发生溶解过程,溶解的药物通过介质扩散。我们在本文中的主要目标是提出一种稳定的有限差分方法,该方法导致流体、固体和溶解药物浓度的超收敛近似。建议的分析是非标准的,因为误差估计在稳定性分析中具有重要作用。