The absolute configuration of rakicidin C was predicted by comparison of optical rotation data and absolute configuration of APD-cyclic depsipeptides and further determined by total synthesis. The absolute configuration of five chiral centers was determined as 2R, 15R, 16R, 17S, and 19S. Our efficient route involves 19 longest linear steps with an overall yield of 1.49%.

中文翻译：

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Rakicidin C 绝对构型的全合成及测定

rakicidin C 的绝对构型是通过比较旋光数据和 APD 环缩肽的绝对构型来预测的，并通过全合成进一步确定。五个手性中心的绝对构型确定为 2 R、 15 R、 16 R、 17 S和 19 S。我们的高效路线涉及 19 个最长的线性步骤，总产率为 1.49%。