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Total Synthesis of the Phosphorylated Zwitterionic Trisaccharide Repeating Unit of Photorhabdus temperata cinerea 3240
Organic Letters ( IF 4.9 ) Pub Date : 2021-08-30 , DOI: 10.1021/acs.orglett.1c02487
Krishna Puri 1 , Suvarn S Kulkarni 1
Affiliation  

Herein, we report the total synthesis of the phosphorylated zwitterionic trisaccharide repeating unit of Photorhabdus temperata subsp. cinerea 3240. The efficient route involves regio- and stereoselective assembly of trisaccharide with rare deoxyamino sugar AAT at the nonreducing end, late stage oxidation, and installation of a phosphate linker on the trisaccharide. The total synthesis was completed via a longest linear sequence of 24 steps in 6.5% overall yield.

中文翻译:

Photorhabdus tempata cinerea 3240 磷酸化两性离子三糖重复单元的全合成

在此,我们报告了Photorhabdus tempata subsp的磷酸化两性离子三糖重复单元的全合成。cinerea 3240. 有效途径包括三糖与稀有脱氧氨基糖 AAT 在非还原端的区域选择性和立体选择性组装、后期氧化以及在三糖上安装磷酸酯接头。总合成通过最长的 24 步线性序列以 6.5% 的总产率完成。
更新日期:2021-09-17
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