Dehydrogenative Aza-[4 + 2] Cycloaddition of Amines with 1,3-Dienes via Dual Catalysis,Organic Letters

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Dehydrogenative Aza-[4 + 2] Cycloaddition of Amines with 1,3-Dienes via Dual Catalysis
Organic Letters ( IF 4.9 ) Pub Date : 2021-08-30 , DOI: 10.1021/acs.orglett.1c02558
Xiaoxiao Chen ₁ , Guoxiang Zhang ₁ , Rong Zeng _{1,

2}

Affiliation

We describe a synergistic utilization of copper catalysis and proton-transfer catalysis that enables an atom- and step-economical aza-[4 + 2] cycloaddition reaction of readily available N-arylamino carbonyl compounds with simple 1,3-dienes. The reaction proceeds smoothly under an air atmosphere and produces water as the sole side product. Whereas the amines can directly serve as the C- and N-atom donors, this operationally simple protocol provides green, rapid, and efficient access to 1,2,3,6-tetrahydropyridines with a broad scope.

中文翻译：

通过双催化脱氢 Aza-[4 + 2] 胺与 1,3-二烯的环加成反应

我们描述了铜催化和质子转移催化的协同利用，使容易获得的N-芳基氨基羰基化合物与简单的 1,3-二烯进行原子和步骤经济的氮杂-[4 + 2] 环加成反应。反应在空气气氛下顺利进行，并产生水作为唯一的副产物。虽然胺可以直接作为 C 和 N 原子供体，但这种操作简单的方案提供了绿色、快速和高效的 1,2,3,6-四氢吡啶，范围广泛。

更新日期：2021-09-17

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