Four New Triterpenoid Saponins from the Root of Ilex centrochinensis,Chemistry & Biodiversity

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Four New Triterpenoid Saponins from the Root of Ilex centrochinensis
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-08-30 , DOI: 10.1002/cbdv.202100343
Hang Yang ₁ , Yan-Xia Lu ₁ , Yu Shi ₁ , Xue-Ying Deng ₁ , Ying-Tao Yi ₁ , Lu-Jun Li _{1,

2,

3} , Ze-Hua Hu ₄

Affiliation

One new siaresinolic acid saponin (1) and three new rotundic acid saponins (2–4) were isolated from the roots of Ilex centrochinensis. Their structures were confirmed by detailed analysis of standard spectroscopic data (IR, MS, 1D and 2D NMR). Compounds 1–4 exhibited anti-inflammatory activity by inhibiting nitric oxide production in a lipopolysaccharide-induced RAW264.7 cell inflammatory model. However, they showed no significant lipid-lowering activity against the production of triglycerides in the lipid-accumulation model of HepG2 cells induced by oleic acid.

中文翻译：

冬青根中四种新的三萜皂苷

一个新siaresinolic酸皂苷（1）和三个新rotundic酸皂甙（2 - 4）从根部分离冬青centrochinensis。它们的结构通过对标准光谱数据（IR、MS、1D 和 2D NMR）的详细分析得到证实。化合物1 - 4通过抑制一氧化氮的产生在脂多糖诱导的RAW264.7细胞炎症模型，表现出抗炎活性。然而，在油酸诱导的 HepG2 细胞脂质积累模型中，它们对甘油三酯的产生没有显示出显着的降脂活性。

更新日期：2021-08-30

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