Magnetic nanoparticles (MNP) and silicon-decorated magnetic nanoparticles (SMNP) have been the object of interest in numerous industry fields as diverse as information storage, diagnostics and imaging, and water treatment thanks to their magnetic properties, which confer them the ability to navigate remotely to a specific location, retrieve material, and vibrate without harmful radiation. However, like all chemical agents, the nanoparticles require pinpoint regulations to ensure proper handling, use, and disposal once their use is finished. The human body's exposition can lead to unknown effects once these particles reach internal structures, like the vascular system. The results show that concentrations of MNP (1–1000 μg/ml) induced alteration on the cardiovascular physiology, on the cardiac contractility, and in the perfusion pressure. Parameters that also were associated with the alteration on nitric oxide (NO) levels, a free radical which regulate the vascular tone, effects displayed from the first administration of the lowest concentration derived from a sustained constriction, which also induced inhibition of the relaxation by the vasoactive substance acetylcholine (ACh), and the blockage of norepinephrine (NE), respectively.

磁性纳米粒子 (MNP) 和硅装饰磁性纳米粒子 (SMNP) 因其磁性而成为众多行业领域的关注对象，包括信息存储、诊断和成像以及水处理，这赋予它们导航能力远程到特定位置，检索材料，并在没有有害辐射的情况下振动。然而，与所有化学试剂一样，纳米粒子需要精确的规定，以确保在使用结束后进行适当的处​​理、使用和处置。一旦这些粒子到达血管系统等内部结构，人体的暴露可能会导致未知的影响。结果表明，MNP 的浓度 (1–1000 μg/ml) 会引起心血管生理、心脏收缩力和灌注压的改变。