A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective,European Journal of Medicinal Chemistry

当前位置： X-MOL 学术 › Eur. J. Med. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2021-08-30 , DOI: 10.1016/j.ejmech.2021.113815
Jiayun Wang ₁ , Feihu Gong ₂ , Ting Liang ₁ , Zhao Xie ₁ , Yingxiang Yang ₁ , Chenyu Cao ₁ , Jinming Gao ₁ , Tao Lu ₃ , Xin Chen ₁

Affiliation

1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural products (NPs) and synthetic compounds which show a variety of pharmacological activities. In this article, we reviewed the design, structures and biological characteristics of reported synthetic THβC compounds, and structure and activity relationship (SAR) of them were also discussed. This work might provide a reference for subsequent drug development based on THβC.

中文翻译：