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A new approach for analysis of polyprenols by a combination of thin-film chemical deposition and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2021-08-30 , DOI: 10.1002/rcm.9185
Alexey S Gladchuk 1, 2 , Konstantin A Krasnov 1 , Olga A Keltsieva 1, 3 , Yana K Kalninia 4 , Marina L Alexandrova 1 , Nikita S Ivanov 2 , Marat Z Muradymov 3 , Nikolai V Krasnov 3 , Vladimir L Reynyuk 1 , Nikolai G Sukhodolov 2 , Ekaterina P Podolskaya 1, 3
Affiliation  

The polyprenols are involved in some essential biosynthetic pathways and serve as ubiquitous components of cellular membranes, so their fingerprinting in natural samples is of great interest. Previous studies indicate that due to the high hydrophobicity of polyprenols their direct analysis by mass spectrometry with soft ionization techniques may be difficult and require preliminary off-line derivatization. Hence, a method for rapid and sensitive screening of polyprenols is required.

中文翻译:

一种结合薄膜化学沉积和基质辅助激光解吸/电离飞行时间质谱法分析聚异戊二烯醇的新方法

聚异戊二烯醇参与了一些重要的生物合成途径,并作为细胞膜的普遍成分,因此它们在天然样品中的指纹识别非常有趣。先前的研究表明,由于聚异戊二烯醇的高疏水性,通过质谱法和软电离技术对其进行直接分析可能很困难,并且需要初步离线衍生化。因此,需要一种快速灵敏地筛选聚异戊二烯醇的方法。
更新日期:2021-09-21
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