Offspring of Preeclampsia (PreE) and HELLP Syndrome are at an increased risk of developing neurodevelopmental disorders. In the current study we sought to determine if offspring from experimental models of PreE and HELLP had evidence of early onset neurodevelopmental delay. Offspring from PreE, HELLP and normal pregnant dams were assessed in a battery of sensorimotor tests beginning on postnatal day (PND) 3. Male HELLP offspring showed altered behavior in the surface righting reflex on PND 3 and cliff avoidance task from PND 3–6 relative to other groups. Results suggest that there are sex differences in offspring born to dams with PreE and HELLP.

先兆子痫 (PreE) 和 HELLP 综合征的后代患神经发育障碍的风险增加。在目前的研究中，我们试图确定 PreE 和 HELLP 实验模型的后代是否具有早发性神经发育迟缓的证据。PreE、HELLP 和正常怀孕水坝的后代在出生后一天 (PND) 3 开始的一系列感觉运动测试中进行了评估。雄性 HELLP 后代在 PND 3 的表面翻正反射和 PND 3-6 亲属的悬崖回避任务中表现出改变的行为到其他组。结果表明，PreE 和 HELLP 母系所生的后代存在性别差异。