U-shaped association between dietary zinc intake and new-onset diabetes: A nationwide cohort study in China,The Journal of Clinical Endocrinology & Metabolism

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U-shaped association between dietary zinc intake and new-onset diabetes: A nationwide cohort study in China
The Journal of Clinical Endocrinology & Metabolism ( IF 5.0 ) Pub Date : 2021-08-27 , DOI: 10.1210/clinem/dgab636
Panpan He ₁ , Huan Li ₁ , Mengyi Liu ₁ , Zhuxian Zhang ₁ , , Yuanyuan Zhang ₁ , Chun Zhou ₁ , Qinqin Li ₂ , Chengzhang Liu _{1,

2} , Xianhui Qin ₁

Affiliation

Abstract

Aims

We aimed to investigate the relationship of dietary zinc intake with new-onset diabetes among Chinese adults.

Materials and Methods

16,257 participants who were free of diabetes at baseline from the China Health and Nutrition Survey (CHNS) were included. Dietary intake was measured by 3 consecutive 24-hour dietary recalls combined with a household food inventory. Participants with self-reported physician-diagnosed diabetes, or fasting glucose ≥7.0 mmol/L or glycated hemoglobin ≥6.5% during the follow-up were defined as having new-onset diabetes.

Results

A total of 1,097 participants developed new-onset diabetes during a median follow-up duration of 9.0 years. Overall, the association between dietary zinc intake and new-onset diabetes followed a U-shape (P for nonlinearity <0.001). The risk of new-onset diabetes was significantly lower in participants with zinc intake <9.1 mg/day (per mg/day: HR, 0.73; 95% CI, 0.60-0.88), and higher in those with zinc intake ≥9.1 mg/day (per mg/day: HR, 1.10; 95%CI, 1.07-1.13). Consistently, when dietary zinc intake was assessed as deciles, compared with those in deciles 2-8 (8.9 -<12.2mg/day), the risk of new-onset diabetes was higher for decile 1 (<8.9mg/day: HR,1.29; 95%CI, 1.04-1.62), and deciles 9-10 (≥12.2mg/day: HR,1.62; 95%CI, 1.38-1.90). Similar U-shaped relations were found for plant-derived or animal-derived zinc intake with new-onset diabetes (all P for nonlinearity <0.001).

Conclusions

There was a U-shaped association between dietary zinc intake and new-onset diabetes in general Chinese adults, with an inflection point at about 9.1 mg/day.

更新日期：2021-08-29

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