Based on the published animal studies, we systematically evaluated the outcomes of various materials for rotator cuff repair in animal models and the potentials of their clinical translation. 74 animal studies were finally included, of which naturally derived biomaterials were applied the most widely (50.0%), rats were the most commonly used animal model (47.0%), and autologous tissue demonstrated the best outcomes in all animal models. The biomechanical properties of naturally derived biomaterials (maximum failure load: WMD 18.68 [95%CI 7.71–29.66]; P = 0.001, and stiffness: WMD 1.30 [95%CI 0.01–2.60]; P = 0.048) was statistically significant in the rabbit model. The rabbit model showed better outcomes even though the injury was severer compared with the rat model.

根据已发表的动物研究，我们系统地评估了各种材料在动物模型中修复肩袖的效果及其临床转化的潜力。最终纳入74项动物研究，其中天然来源的生物材料应用最广泛（50.0%），大鼠是最常用的动物模型（47.0%），自体组织在所有动物模型中表现出最好的结果。天然生物材料的生物力学特性（最大失效载荷：WMD 18.68 [95%CI 7.71–29.66]；P = 0.001，刚度：WMD 1.30 [95%CI 0.01–2.60]；P = 0.048）在兔子模型。尽管与大鼠模型相比，兔子模型的损伤更严重，但表现出更好的结果。