UV–vis spectrometry is widely used in the pharmaceutical sciences for compound quantification, alone or in conjunction with separation techniques, due to most drug entities possessing a chromophore absorbing light in the range 190–800 nm. UV dissolution imaging, the scope of this review, generates spatially and temporally resolved absorbance maps by exploiting the UV absorbance of the analyte. This review aims to give an introduction to UV dissolution imaging and its use in the determination of intrinsic dissolution rates and drug release from whole dosage forms. Applications of UV imaging to non-oral formulations have started to emerge and are reviewed together with the possibility of utilizing UV imaging for physical chemical characterisation of drug substances. The benefits of imaging drug diffusion and transport processes are also discussed.

由于大多数药物实体具有 190-800 nm 范围内的发色团吸收光，紫外-可见分光光度法在药物科学中广泛用于化合物定量，单独或与分离技术结合使用。紫外溶解成像，本综述的范围，通过利用分析物的紫外吸光度生成空间和时间分辨的吸光度图。本综述旨在介绍紫外溶出成像及其在确定固有溶出速率和整个剂型药物释放中的应用。紫外成像在非口服制剂中的应用已经开始出现，并与利用紫外成像对药物进行物理化学表征的可能性一起进行了审查。还讨论了成像药物扩散和转运过程的好处。