Diabetic mellitus (DM) is a common degenerative chronic metabolic disease often accompanied by severe cardiovascular complications (DCCs) as major causes of death in diabetic patients with diabetic cardiomyopathy (DCM) as the most common DCC. The metabolic disturbance in DCM generates the conditions/substrates and inducers/triggers and activates the signaling molecules and death executioners leading to cardiomyocyte death which accelerates the development of DCM and the degeneration of DCM to heart failure. Various forms of programmed active cell death including apoptosis, pyroptosis, autophagic cell death, autosis, necroptosis, ferroptosis and entosis have been identified and characterized in many types of cardiac disease. Evidence has also been obtained for the presence of multiple forms of cell death in DCM. Most importantly, published animal experiments have demonstrated that suppression of cardiomyocyte death of any forms yields tremendous protective effects on DCM. Herein, we provide the most updated data on the subject of cell death in DCM, critical analysis of published results focusing on the pathophysiological roles of cell death, and pertinent perspectives of future studies.

糖尿病（DM）是一种常见的退行性慢性代谢性疾病，常伴有严重的心血管并发症（DCC），是糖尿病患者死亡的主要原因，其中糖尿病心肌病（DCM）是最常见的DCC。 DCM中的代谢紊乱产生条件/底物和诱导物/触发物，并激活信号分子和死亡执行者，导致心肌细胞死亡，从而加速DCM的发展和DCM退化为心力衰竭。多种形式的程序性主动细胞死亡，包括细胞凋亡、细胞焦亡、自噬性细胞死亡、自体死亡、坏死性凋亡、铁死亡和嵌入，已在许多类型的心脏病中得到鉴定和表征。还获得了 DCM 中存在多种形式的细胞死亡的证据。最重要的是，已发表的动物实验表明，抑制任何形式的心肌细胞死亡都会对 DCM 产生巨大的保护作用。在此，我们提供有关 DCM 细胞死亡主题的最新数据、对已发表结果的批判性分析（重点关注细胞死亡的病理生理学作用）以及未来研究的相关观点。