The reaction of N-arylbenzenecarboximidamides 1a-e with succinic anhydride 2 was studied, leading to the formation of (Z)-1-phenyl(arylamino)methylpyrrolidine-2,5-diones 3a-e in good yields. The structure of the obtained compounds was proved by ¹H, ¹³C NMR, IR, MS (ESI) and elemental analyzes. For (Z)-1-phenyl(phenylamino)methyl)pyrrolidine-2,5-dione 3a, an X-ray diffraction analysis was performed and an in vivo study of analgesic activity in laboratory mice was carried out.

中文翻译：

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作为潜在镇痛剂的新型 (Z)-1-苯基(芳基氨基)甲基吡咯烷-2,5-二酮衍生物的有效合成和表征

研究了N-芳基苯甲酰亚胺酰胺1a-e与琥珀酸酐2 的反应，导致以良好的产率形成 (Z)-1-苯基(芳氨基)甲基吡咯烷-2,5-二酮3a-e。所得化合物的结构经¹ H、¹³ C NMR、IR、MS (ESI)和元素分析证实。对于 (Z)-1-苯基(苯基氨基)甲基)吡咯烷-2,5-二酮3a，进行了 X 射线衍射分析，并在实验室小鼠中进行了镇痛活性的体内研究。