ABSTRACT

Feeding studies were conducted with rats and broiler chickens to assess the safety and nutrition of maize grain containing event DP-Ø23211-2 (DP23211), a newly developed trait-pyramid product for corn rootworm management. Diets containing 50% ground maize grain from DP23211, non-transgenic control, or non-transgenic reference hybrids (P0928, P0993, and P1105) were fed to Crl:CD®(SD) rats for 90 days. Ross 708 broilers were fed phase diets containing up to 67% maize grain from each source for 42 days. Body weight, gain, and feed conversion were determined for comparisons between animals fed DP23211 and control diets in each study. Additional measures included clinical and neurobehavioral evaluations, ophthalmology, clinical pathology, organ weights, and gross and microscopic pathology for rats, and carcass parts and select organ yields for broilers. Reference groups were included to determine if any observed significant differences between DP23211 and control groups were likely due to natural variation. No diet-related effects on mortality or evaluation measures were observed between animal fed diets produced with DP23211 maize grain and animal fed diets produced with control maize grain. These studies show that maize grain containing event DP-Ø23211-2 is as safe and nutritious as non-transgenic maize grains when fed in nutritionally adequate diets. The results are consistent with previously published studies, providing further demonstration of the absence of hazards from edible-fraction consumption of genetically modified plants.

 抽象的

对大鼠和肉鸡进行喂养研究，以评估含有事件 DP-Ø23211-2 (DP23211) 的玉米粒的安全性和营养性，事件 DP-Ø23211-2 是一种新开发的用于玉米根虫管理的性状金字塔产品。将含有来自 DP23211、非转基因对照或非转基因参考杂种（P0928、P0993 和 P1105）的 50% 磨碎玉米粒的饮食喂给 Crl:CD®(SD) 大鼠 90 天。 Ross 708 肉鸡在 42 天内饲喂各来源玉米粒含量高达 67% 的阶段日粮。测定体重、增重和饲料转化率，以对每项研究中饲喂 DP23211 和对照饮食的动物进行比较。其他指标包括大鼠的临床和神经行为评估、眼科、临床病理学、器官重量以及肉眼和显微病理学，以及肉鸡的屠体部位和精选器官产量。纳入参考组是为了确定 DP23211 和对照组之间观察到的任何显着差异是否可能是由于自然变异造成的。在用 DP23211 玉米粒生产的动物饲料和用对照玉米粒生产的动物饲料之间，没有观察到与饮食相关的对死亡率或评估措施的影响。这些研究表明，当以营养充足的饮食喂养时，含有事件 DP-Ø23211-2 的玉米粒与非转基因玉米粒一样安全且营养丰富。结果与之前发表的研究一致，进一步证明食用转基因植物的可食用部分不存在危害。