Central obesity, measured by the waist circumference (WC) or waist-to-hip ratio, has been linked with metabolic dysfunction and structural abnormalities in the brain, two risk factors for cognitive impairment and dementia. The current analysis was performed to understand the influence of central obesity on the incidence of cognitive impairment and dementia. It included 21 studies involving 5,060,687 participants and showed that a high WC was associated with a greater risk of cognitive impairment and dementia (HR = 1.10, 95 % CI: 1.05–1.15), compared with a low WC. Sub-group analysis showed that a high WC increased the likelihood of developing cognitive impairment and dementia in individuals older than 65 years of age (HR = 1.13, 95 % CI: 1.08–1.19), whereas no association was observed in individuals younger than 65 years of age (HR = 1.04, 95 % CI: 0.93–1.16). Furthermore, dose-response meta-analysis confirmed that a high WC was a risk factor for cognitive impairment and dementia. In conclusion, central obesity, as measured by WC, was associated with a risk of cognitive impairment and dementia.

以腰围 (WC) 或腰臀比衡量的向心性肥胖与大脑的代谢功能障碍和结构异常有关，这是认知障碍和痴呆的两个危险因素。目前的分析是为了了解中心性肥胖对认知障碍和痴呆发生率的影响。它包括 21 项研究，涉及 5,060,687 名参与者，并表明与低 WC 相比，高 WC 与更大的认知障碍和痴呆风险相关（HR = 1.10，95 % CI：1.05–1.15）。亚组分析表明，高 WC 增加了 65 岁以上个体发生认知障碍和痴呆的可能性（HR = 1.13，95 % CI：1.08-1.19），而在 65 岁以下的个体中未观察到相关性岁（HR = 1.04，95 % CI：0.93–1.16）。此外，剂量反应荟萃分析证实，高 WC 是认知障碍和痴呆的危险因素。总之，通过WC测量的向心性肥胖与认知障碍和痴呆的风险相关。