Recent Progress of Extracellular Vesicle Engineering,ACS Biomaterials Science & Engineering

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Recent Progress of Extracellular Vesicle Engineering
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-08-28 , DOI: 10.1021/acsbiomaterials.1c00868
Xuemei Jia ₁ , Jianpu Tang ₁ , Chi Yao ₁ , Dayong Yang ₁

Affiliation

Extracellular vesicles (EVs) are nanoscale phospholipid bilayer membrane vesicles which contain varied active biomolecules. As natural carriers, EVs can deliver endogenous cargos to target tissues safely and effectively. However, the applications of natural released EVs are limited by their low yield and heterogeneity. Engineering EVs can endow them with more functions and better performances to address these issues. EVs can be modified and engineered to improve the yield, targeting efficiency, and content of beneficial cargos. Herein, the strategies of engineering EVs through genetic modification of EVs are introduced; the molecular modification of the EV membrane and the loading of nucleic acids are summarized; the building of EV mimetic nanovesicles are reviewed. Overall, we anticipate that readers will gain a better understanding of the progress of EV engineering, which will help to promote the development of the technologies and applications in this field.

中文翻译：

细胞外囊泡工程的最新进展

细胞外囊泡 (EV) 是纳米级磷脂双层膜囊泡，含有多种活性生物分子。作为天然载体，电动汽车可以安全有效地将内源性货物输送到目标组织。然而，自然释放的电动汽车的应用受到其低产量和异质性的限制。工程电动汽车可以赋予它们更多的功能和更好的性能来解决这些问题。电动汽车可以进行修改和设计，以提高产量、目标效率和有益货物的含量。在此，介绍了通过EVs基因改造工程化EVs的策略；总结了EV膜的分子修饰和核酸的加载；EV 模拟纳米囊泡的构建进行了审查。总体，

更新日期：2021-09-13

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