Purpose: With increasing breast cancer (BC) survival rates, the survivors quality of life (QoL) has become an important issue. Chemotherapy-induced cognitive impairment, known as chemobrain has been addressed recently. Therefore, cognitive function as one of the determinants of QoL should be considered while prescribing chemotherapeutics. In this study, we aimed to evaluate the effects of two common chemotherapy regimens on BC survivors cognition. Methods: The participants comprised 35 BC patients who underwent two common chemotherapy regimens, AC-T and TAC, and 24 matched healthy volunteers. The participants were assessed regarding anxiety, depression, general health status, and cognitive function including aspects of concentration, verbal ability, reasoning, memory, and visuospatial skill through Addenbrookes Cognitive Examination (ACE-P) and Cambridge Brain Science (CBS) tests. Results: Regarding depression and anxiety, there were no significant differences between the three groups. However, BC patients significantly complained of chronic fatigue compared to healthy volunteers (P-value = 0.027). Besides, ACE-P revealed the language domain to be affected in the AC-T group in comparison with the TAC-treated cases (P-value = 0.036). Moreover, the patients receiving the AC-T regimen had worse performance in visuospatial working memory and attention domains compared to the TAC group considering CBS tests (P-value = 0.031 and 0.008, respectively). Conclusion: The results represent the AC-T regimen to be more toxic than the TAC in domains of language, concentration, and visuospatial working memory. Implications for cancer survivors: The AC-T regimen should be prescribed with caution in BC patients suffering from baseline cognitive impairments to improve post-chemotherapy QoL.

中文翻译：

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乳腺癌患者化疗相关认知障碍的比较分析：一项基于社区的研究

目的：随着乳腺癌 (BC) 存活率的提高，幸存者的生活质量 (QoL) 已成为一个重要问题。最近解决了化疗引起的认知障碍，称为化学脑。因此，在开具化疗药物的处方时，应考虑认知功能作为 QoL 的决定因素之一。在这项研究中，我们旨在评估两种常见化疗方案对 BC 幸存者认知的影响。方法：参与者包括 35 名接受两种常见化疗方案 AC-T 和 TAC 的 BC 患者，以及 24 名匹配的健康志愿者。对参与者的焦虑、抑郁、一般健康状况和认知功能进行了评估，包括注意力、语言能力、推理、记忆、通过 Addenbrookes 认知考试 (ACE-P) 和剑桥脑科学 (CBS) 测试提高视觉空间技能。结果：在抑郁和焦虑方面，三组之间没有显着差异。然而，与健康志愿者相比，BC 患者显着抱怨慢性疲劳（P 值 = 0.027）。此外，与 TAC 治疗的病例相比，ACE-P 显示 AC-T 组的语言域受到影响（P 值 = 0.036）。此外，与考虑 CBS 测试的 TAC 组相比，接受 AC-T 方案的患者在视觉空间工作记忆和注意力领域的表现更差（P 值分别为 0.031 和 0.008）。结论：结果表明 AC-T 方案在语言、浓度和视觉空间工作记忆领域比 TAC 更具毒性。