Benzimidazole based derivatives as anticancer agents: Structure activity relationship analysis for various targets,Journal of Heterocyclic Chemistry

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Benzimidazole based derivatives as anticancer agents: Structure activity relationship analysis for various targets
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2021-08-28 , DOI: 10.1002/jhet.4355
Garvit Satija ₁ , Barkha Sharma ₁ , Anish Madan ₁ , Ashif Iqubal ₂ , M. Shaquiquzzaman ₁ , Mymoona Akhter ₁ , Suhel Parvez ₃ , Mohammad Ahmed Khan ₂ , M. Mumtaz Alam ₁

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Benzimidazole, the benzo derivative of imidazole, is a class of bicyclic aromatic organic compound consisting of six-membered benzene ring fused to five-membered imidazole at 4- and 5-positions of the imidazole ring. It is a vital pharmacophore of many biologically active heterocyclic compounds with a variety of pharmacological activities. Over the time, benzimidazole and its derivatives have evolved as vibrant heterocyclic systems due to their potency in a wide range of bioactive compounds like analgesics, antifungals, anti-inflammatory, antihypertensives, proton pump inhibitors, anti-HIV, antiviral, and so on. Multi-drug resistance in cancer that led to the failure of many chemotherapeutic drugs is a major concern. Various approaches are being developed to overcome this problem. One of them is target based drug discovery, which is an effective method to develop a novel anticancer drug. To develop newer drugs, previously reported work needs to be studied. Keeping this in mind, last 5 years literature on benzimidazole used as anticancer agents has been reviewed and summarized in the paper herein. This review article along with the target of cancer also deal with structure activity relationship of various compounds having benzimidazole ring.

中文翻译：

苯并咪唑类衍生物作为抗癌剂：各种靶点的结构活性关系分析

苯并咪唑是咪唑的苯并衍生物，是由六元苯环与五元咪唑在咪唑环的4位和5位稠合而成的一类双环芳香族有机化合物。它是许多具有多种药理活性的生物活性杂环化合物的重要药效团。随着时间的推移，苯并咪唑及其衍生物已发展成为充满活力的杂环系统，因为它们在镇痛药、抗真菌药、抗炎药、抗高血压药、质子泵抑制剂、抗 HIV、抗病毒药等多种生物活性化合物中具有效力。导致许多化疗药物失效的癌症中的多药耐药性是一个主要问题。正在开发各种方法来克服这个问题。其中之一是基于目标的药物发现，这是开发新型抗癌药物的有效方法。为了开发更新的药物，需要研究以前报告的工作。牢记这一点，本文对过去 5 年关于苯并咪唑用作抗癌剂的文献进行了回顾和总结。这篇综述文章连同癌症的靶点还讨论了各种具有苯并咪唑环的化合物的构效关系。

更新日期：2021-08-28

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